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Year : 2014  |  Volume : 4  |  Issue : 2  |  Page : 34-36

Simultaneous hepatosplenic T-cell lymphoma and myelofibrosis

1 Department of Pathology, Wayne State University, Detroit, MI 48201, USA
2 Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA
3 Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, The Methodist Hospital Research Institute, Houston, TX, USA
4 Department of Pathology, Case Western Reserve University, Metro Health Medical Center, Cleveland, Ohio, USA

Correspondence Address:
Ali M Gabali
Department of Pathology, Wayne State University, 3990 John R, Detroit, MI 48201
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0770.130343

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Hepatosplenic T-cell lymphoma (HSTL) is a rare T-cell neoplasm of the lymphoid system. This type of lymphoma is characterized by sinusoidal infiltration of spleen, liver, bone marrow and lymph nodes by neoplastic lymphocytes. Here, we discuss a patient who had a left axillary lymph node biopsy with characteristic histological and immunohistochemical features of HSTL. In addition, infiltrating neoplastic T-cells and simultaneous characteristic features of myelofibrosis (MF) were also present in the bone marrow biopsy specimen. In contrast to secondary MF, primary MF is a progressive disease and may significantly affect the prognosis of coexisting HSTL. There are few reports in the literature talking about mild bone marrow fibrosis in association with T cell lymphoma, however marked increase in bone marrow fibrosis and HSTL never being reported. This case is shedding light on HSTL and marked increase in bone marrow fibrosis.

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