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  Indian J Med Microbiol
 

Figure 2: On microscopical examination, the lesion consisted in large vessels and vascular cavities, and disperse bone fragments (a-d: Black asterisk/ vascular cavity; black short arrows/large blood vessels, white asterisks/osseous metaplasia). Several vessels or vascular cavities showed tuft-like wall projections/excrescencies (b and c: Black long arrow). The nodule was limited focally by a connective tissue rim and a fragment of adipose tissue appended (a: White arrows, a inset: Arrowhead for the adipose tissue). The vessel wall was of varied thickness (b: Black short arrows/vascular wall of varied thickness, with smooth-muscle-actin positive layer). Osseous metaplasia was multifocal, disperse in the entire nodule, in the vessel wall and in the sparse connective tissue the vascular structures (a-d: White asterisks). (a, b, and d) H and E stain, b immunohistochemistry for smooth-muscle-actin; original magnification ×2.5 (a, a inset, c); ×5 (b); ×10 (d)

Figure 2: On microscopical examination, the lesion consisted in large vessels and vascular cavities, and disperse bone fragments (a-d: Black asterisk/ vascular cavity; black short arrows/large blood vessels, white asterisks/osseous metaplasia). Several vessels or vascular cavities showed tuft-like wall projections/excrescencies (b and c: Black long arrow). The nodule was limited focally by a connective tissue rim and a fragment of adipose tissue appended (a: White arrows, a inset: Arrowhead for the adipose tissue). The vessel wall was of varied thickness (b: Black short arrows/vascular wall of varied thickness, with smooth-muscle-actin positive layer). Osseous metaplasia was multifocal, disperse in the entire nodule, in the vessel wall and in the sparse connective tissue the vascular structures (a-d: White asterisks). (a, b, and d) H and E stain, b immunohistochemistry for smooth-muscle-actin; original magnification ×2.5 (a,
a inset, c); ×5 (b); ×10 (d)