Nephrotic syndrome after treatment of Crohn's disease with mesalamine: Case report and literature review

Belal M Firwana; Rim Hasan; Walid Chalhoub; Mazen Ferwana; Jin-Yong Kang; Joshua Aron; Joseph Lieber

doi:10.4103/2231-0770.94804


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CASE REPORT

Year : 2012 | Volume : 2 | Issue : 1 | Page : 9-11

Nephrotic syndrome after treatment of Crohn's disease with mesalamine: Case report and literature review

Belal M Firwana¹, Rim Hasan¹, Walid Chalhoub², Mazen Ferwana³, Jin-Yong Kang⁴, Joshua Aron², Joseph Lieber²
¹ Elmhurst Hospital Center, Mount Sinai School of Medicine, Elmhurst, NY; Department of Internal Medicine, University of Missouri, Columbia, MO, USA
² Elmhurst Hospital Center, Mount Sinai School of Medicine, Elmhurst, NY, USA
³ Department of Internal Medicine, King Saud bin Abdualziz University for Health Sciences, Riyadh, Saudi Arabia
⁴ Department of Gastroenterology, St George's Hospital, London, United Kingdom

Correspondence Address:
Joseph Lieber
Department of Medicine, Elmhurst Hospital Center, Mount Sinai Services of The Mount Sinai School of Medicine, 7901 Broadway, Elmhurst, NY 11373
USA

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/2231-0770.94804

Inflammatory bowel disease and its various treatments may affect the kidney in several ways. Recently, case reports have been published documenting the development of nephrotic syndrome after the treatment for inflammatory bowel disease with 5-aminosalicylic acid derivatives. We report a 50-year-old patient who was diagnosed with Crohn's disease and was treated with mesalamine. The patient subsequently developed nephrotic syndrome and a renal biopsy showed minimal change disease. He was treated with losartan and rosuvastatin and showed improvement in his renal function and serum cholesterol level. This is the first reported case in Crohn's disease although there have been six previous case reports of nephrotic syndrome following salicylic acid derivatives for ulcerative colitis.

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