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Year : 2012  |  Volume : 2  |  Issue : 1  |  Page : 9-11

Nephrotic syndrome after treatment of Crohn's disease with mesalamine: Case report and literature review

1 Elmhurst Hospital Center, Mount Sinai School of Medicine, Elmhurst, NY; Department of Internal Medicine, University of Missouri, Columbia, MO, USA
2 Elmhurst Hospital Center, Mount Sinai School of Medicine, Elmhurst, NY, USA
3 Department of Internal Medicine, King Saud bin Abdualziz University for Health Sciences, Riyadh, Saudi Arabia
4 Department of Gastroenterology, St George's Hospital, London, United Kingdom

Correspondence Address:
Joseph Lieber
Department of Medicine, Elmhurst Hospital Center, Mount Sinai Services of The Mount Sinai School of Medicine, 7901 Broadway, Elmhurst, NY 11373
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0770.94804

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Inflammatory bowel disease and its various treatments may affect the kidney in several ways. Recently, case reports have been published documenting the development of nephrotic syndrome after the treatment for inflammatory bowel disease with 5-aminosalicylic acid derivatives. We report a 50-year-old patient who was diagnosed with Crohn's disease and was treated with mesalamine. The patient subsequently developed nephrotic syndrome and a renal biopsy showed minimal change disease. He was treated with losartan and rosuvastatin and showed improvement in his renal function and serum cholesterol level. This is the first reported case in Crohn's disease although there have been six previous case reports of nephrotic syndrome following salicylic acid derivatives for ulcerative colitis.

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